VIP (1 Vial)

Buy VIP peptide (Vasoactive Intestinal Peptide) in a 10 mg lyophilized vial — a 28-amino-acid neuropeptide of the secretin-glucagon superfamily, studied for its roles in immune signaling, smooth muscle relaxation, circadian regulation, and gastrointestinal physiology. Every vial is US manufactured, verified at 99%+ purity by third-party HPLC and mass spectrometry, and ships with a batch-specific certificate of analysis.

What Is VIP Peptide?

Vasoactive intestinal peptide was first isolated from porcine duodenum in 1970 by Said and Mutt, who named it for the pronounced vasodilatory activity they observed in early assays. It is now recognized as one of the most widely distributed neuropeptides in mammalian tissues, expressed throughout the enteric nervous system, the central nervous system, the lungs, and immune compartments.

VIP signals primarily through two class B G-protein-coupled receptors, VPAC1 and VPAC2, and with lower affinity through PAC1. Receptor engagement activates adenylyl cyclase, raising intracellular cAMP and downstream protein kinase A activity — the pathway that underlies most of the effects reported in the literature. Laboratories that buy VIP peptide from us receive the native 28-residue human sequence rather than a truncated analogue. Researchers new to this peptide class often start with our complete guide to research peptides.

Key Research Applications

• Immune modulation: VIP is studied as an endogenous anti-inflammatory mediator that shifts macrophage and T-cell phenotypes in cultured immune models.
• Pulmonary and vascular physiology: Its smooth muscle relaxant activity makes it a frequent tool compound in bronchial and pulmonary vascular research.
• Circadian biology: VIP-expressing neurons of the suprachiasmatic nucleus are central to how animal models synchronize circadian output.
• Gastrointestinal signaling: As an enteric neurotransmitter, VIP is used in studies of intestinal motility, secretion, and epithelial barrier function.

Product Specifications