Sermorelin (1 Vial)

Buy Sermorelin — a 29-amino acid synthetic analog of human growth hormone-releasing hormone (GHRH), available as a ≥99% pure lyophilized powder for research purposes. This peptide (GRF 1-29 NH₂, CAS 86168-78-7) represents the shortest fully bioactive GHRH fragment and carries the strongest regulatory history of any growth hormone secretagogue, having received FDA approval as Geref® from 1997 to 2008.

What Is Sermorelin?

This GHRH analog mirrors the first 29 amino acids of endogenous GHRH — the precise region responsible for full biological activity at the GHRH receptor. Unlike synthetic growth hormone itself, the compound works through the body’s own pituitary axis, stimulating natural GH synthesis and secretion while preserving somatostatin-mediated negative feedback. This mechanism makes it one of the most physiologically elegant tools in GH-axis research. For a broader overview of peptide research, visit our Complete Guide to Peptides.

Key Research Applications

• GH-Axis Physiology: The compound is widely used to study pituitary somatotroph function, GHRH receptor pharmacology, and pulsatile GH secretion dynamics in aging and disease models.
• Somatopause Research: Age-related GH decline (somatopause) is a major research focus; Sermorelin partially restores GH pulsatility in elderly subjects where GHRH receptor sensitivity remains intact.
• Sleep Architecture Studies: Administration of this peptide has been shown to increase slow-wave sleep duration, supporting investigation of the bidirectional relationship between GH secretion and sleep quality.
• Body Composition Models: Researchers use this GHRH analog in studies examining lean mass preservation, fat metabolism, and metabolic hormone interactions under conditions of GH deficiency.
• GHRH Receptor Pharmacology: The well-characterized structure of this 29-amino acid fragment makes it an ideal reference compound for dose-response and receptor-binding studies.

Product Specifications